SPN
SPNs result from the presence of anti-tumor neuro-oncoprotein (intracellular) autoantibodies.
They manifest as abnormalities of the central and peripheral nervous systems, cerebellar degeneration, or sensory neuropathies.
Autoantibodies can be detected up to 5 years before the tumor appears.
The relevant antibodies are: Hu, Yo, and Ri; CV2; Ma2/Ta; amphiphysin; SOX-1; recoverin; Zic4; and Tr(DNER).
If SPN-associated antibodies are detected, the probability of a tumor is 95%; therefore, the presence of these antibodies warrants a thorough search for the tumor.
The associated neoplasms are: small cell lung carcinoma, neuroblastoma, thymoma, and cancers of the ovary, breast, uterus, and testicles.
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CLINICAL PATHOLOGY LABORATORY
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